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180039778Paris: Richard Caille Ravier 1800. 8vo. 326pp. Quarter calf gilt paste paper boards vellum corners hinges a little tender. Faint dampstains on first 20 or so leaves otherwise a clean crisp copy. First Edition. Garrison-Morton 537. The foundation of histology and tissue pathology. Bichat's most important contribution to anatomy was his generalization of Pinel's theory expressed in Nosographie philosophique 1798 that pathology must be based upon the structure of the tissues of which bodily organs are composed regardless of where in the body they occur. Bichat distinguished twenty-one different types of tissue which he classified according to texture and to properties: extensibility contractility and the vital properties-- organic contractility and sensibility "insensible" or "subliminal" on the one hand and animal contractility and sensibility "sensible" or "conscious" on the other. Each tissue differed in its diseases as diseases were nothing more than alterations in the tissue's vital properties. Claude Bernard said of Bichat that he "decentralized life and incarnated it in the tissues" quoted in Hall II p. 129 and that his ideas were the source of modern opinions concerning vital phenomena. Heirs of Hippocrates 1256. Norman 230. Richard, Caille, Ravier unknown books