Pharmacologie

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American Society for Pharmacology and Experimental TherapeuticsBiblio.com

Vane, Sir John R; & Dr Jack Botting; Dr Regina Botting (editors)Biblio.com

Improved Non-Steroid Anti-Inflammatory Drugs : Cox-2 Enzyme Inhibitors

1996004361Dordrecht Boston London:: Kluwer Academic Publishers / William Harvey Press 1996. Heavy erasure on title page else a bright clean square tight copy. No owner's name or bookplate. No remainder marks. Pages are fresh and crisp. No underlining. No highlighting. No margin notes. Bound in the original maroon pictorial boards. Proceedings of a Conference Held on October 10-11 1995 at Regent's College London. Contains 13 papers: 1 Overview - mechanisms of action of anti-inflammatory drugs; 2 The three-dimensional structure of cyclooxygenases; 3 The dilemma of two-cyclooxygenases: identifying the role of COX-1 and COX-2 in inflammation and apoptosis; 4 Inducible enzymes with special reference to COX-2 in the inflammatory response; 5 NSAID mechanism of action: the role of intracellular pharmacokinetics; 6 Differential inhibition of COX-1 and COX-2 in vitro and pharmacological profile in vivo of NSAIDs; 7 COX-2 expression and inhibition in human monocytes; 8 Expression and regulation of COX-2 in synovial tissues of arthritic patients; 9 An inhibitor of injury-induced COX-2 transcriptional activation elicits neuroprotection in a brain damage model; 10 COX-2 expression in labour; 11 Re-evaluation of gut toxicity of NSAIDs; 12 NSAID: can renal side effects be avoided; 13 Pharmacology safety data and therapeutics of COX-2 inhibitors. Bibliographical references. Index. From the rear cover: "This volume is the proceedings of the William Harvey Conference held in London on the 10th and 11th October 1995. It covers the molecular biology and physiological functions of the cyclooxygenase enzymes as well as the experimental and clinical aspects of the recently discovered inhibitors of the inducible cyclooxygenase. Particular attention has been directed at the discussion of the selectivity of non-steroid anti-inflammatory drugs for cyclooxygenase-2 and their propensity to cause gastric and kidney damage. Sir John Vane is the Director General Regina Botting the Information Scientist and Jack Botting Consultant at the William Harvey Research Institute an independent charitable foundation carrying out research into cardiovascular disease inflammation and metabolic disorders within Queen Mary and Westfield College of the University of London UK. Sir John Vane was awarded the Nobel Prize in 1982 for his discoveries of the mechanism of action of aspirin and of the physiological role of prostacyclin and other prostanoids.". First Edition. Hard Cover. Near Fine condition./No Dust Jacket as issued. 8vo. ix 241pp. Kluwer Academic Publishers / William Harvey Press Hardcover

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